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Before you upload the document to a website, double-check your work. Make sure all links function properly. If any of the document links are to a website, make sure you have the correct URL. Nothing is more frustrating for a web visitor than trying to open a link and getting a Not Found error. Remember to test your links in a browser; otherwise, Acrobat will append the current document with the web page specified in the link.
If all the links are formatted properly, choose File | Save As | Optimized PDF. This opens the PDF Optimizer. With the PDF Optimizer, you can remove any bookmarks or links with invalid destinations, and reduce the file size by specifying compression settings for images in the document and removing unused objects. If you created any named destinations that you intend to use as link destinations from an HTML document or other PDF document, deselect the Discard Unreferenced Named Destinations check box in the Clean Up section of the PDF Optimizer, shown here.