Dedication We dedicate this book to the memory of Hubert J. P. Schoemaker, our beloved brother and brother-in-law, who was a genuine pioneer of the new biosciences. After finishing his Ph.D. in biochemistry at MIT in 1977 and working briefly for Corning Biomedical, Hubert joined a small group of scientists and entrepreneurs in 1979 to found one of America's first biotech companies, Centocor Inc. It became the leader in the exciting new field of monoclonal antibody technology, moving gradually from diagnostics into therapeutics. The company could be the poster child for the roller-coaster ride typical of many biotech companies. Its stock dropped from $60 per share to less than $6 per share when the FDA failed to approve its promising drug Centoxin for septic shock in 1992. Through alliances with Eli Lilly and other established pharma companies, Centocor rose from the ashes with an anticlotting medicine for coronary disease (ReoPro), followed by a major blockbuster drug for Crohn's disease, rheumatoid arthritis, and other autoimmune diseases (Remicade). Hubert lived through these ups and down as president,