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8. Multiplicity and Persistency of Synap... > 8-3. Synaptic Plasticity in Basket/S...

8-3. Synaptic Plasticity in Basket/Stellate Cells

LTP and LTD in parallel fiber-basket/stellate cell synapses. Burst stimulation of a parallel fiber bundle unpaired with climbing fiber activity induces a long-lasting decrease in the size of the receptive fields of inhibitory interneurons. At the same time, it causes a large increase in the size of the receptive fields of Purkinje cells (Jörntell and Ekerot, 2002, 2003). In contrast, parallel fiber stimulation paired with climbing fiber activity induces a long-lasting increase in the size of receptive fields in interneurons, whereas it causes a long-lasting decrease in the size of the receptive fields of Purkinje cells. These findings suggest that parallel fiber synapses in inhibitory interneurons undergo LTP when parallel fiber synapses in Purkinje cells undergo LTD, and vice versa. Such a reciprocal pattern may have a synergistic effect, which augments the information storage capacity of cerebellar cortical networks. Alternatively, the parallel fiber-Purkinje cell synapses and parallel fiber-basket/stellate cell synapses may share different roles in the operation of cerebellar circuits. For example, a computer simulation study adopted such an assumption that synaptic plasticity first developed in parallel fiber-Purkinje cell synapses, and with additional training, this was transferred to parallel fiber-basket/stellate cell synapses for long-term memory storage (Kenyon, 1997).


  

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