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8. Multiplicity and Persistency of Synap... > 8-4. Synaptic Plasticity in Other Ce...

8-4. Synaptic Plasticity in Other Cerebellar Cortical Synapses

LTP in mossy fiber-granule cell synapses. High-frequency mossy fiber stimulation induces LTP in mossy fiber-granule cell synapses, providing postsynaptic NMDA receptors are activated. This LTP is accompanied by significant NO release in the granular layer, which is also dependent on NMDA receptor activation as well as NO synthase activation (Maffei et al., 2003). LTP is one of the processes that regulate the degree of divergence from a mossy fiber to granule cells (D’Angelo et al., 1999) in addition to the enhancement of intrinsic excitability (Armano et al., 2000) and Golgi cell inhibition (Chadderton et al., 2004).

Long-term changes in Golgi cell responses. Effects of conjunctive stimulation of climbing fibers and peripheral afferents on Golgi cells have been examined (Xu and Edgley, 2008) because anatomical evidence has shown that Golgi cells are contacted by climbing fibers, and because climbing fiber signals may be transferred to Golgi cells by spillover of the transmitter or via synapses with NG2+ glial cells (Chapter 5, “Inhibitory Interneurons and Glial Cells in the Cerebellar Cortex”). After the conjunction, Golgi cell responses to peripheral afferent stimulation were significantly reduced. The reductions developed progressively over 20 minutes of conjunctive stimulation and were persistent for up to 84 minutes. These results are in keeping with the idea that cerebellar circuits contribute to learning mechanisms.


  

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