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Some designers, like independent designer and web strategist Jason Pamental (thinkinginpencil.com) interviewed below, prefer to do site prototyping directly in the browser. For Pamental, doing things this way gives you the opportunity to see things as they actually behave in the browser, rather than mocking things up in Photoshop or Fireworks only to spend hours explaining to clients why the designs changed once they were implemented in Drupal.
The trick to this approach, however, is not falling into the trap of simply decorating on top of what Drupal gives you—but rather, as Todd Nienkerk suggests in his Drupalcon session, Don’t Design Websites, Design Web SYSTEMS!,[9] letting Drupal’s default behavior simply provide a guide your design decisions.