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The water-soluble vitamins do not have to be eaten with fat to be absorbed, and it’s harder to overdose on these vitamins, as the body can flush them out via the urine. This doesn’t make these substances—the eight B-complex vitamins and vitamin C—any more innocuous or less important than the fat-soluble ones, though. Some of the most infamous nutrient-related diseases are caused by deficiencies in C (scurvy), thiamine (beriberi), and niacin (pellagra).