Negotiating Meaning Positioning ourselves in a middle ground we dismantle mediation taking actor-network as- sertions (reductions, amplifications, framings) to find transversal referents (Latour, 1993a) that allows the emergence of meaning along the con- struct of artefacts. We reuse the semiotic Latour concepts of procession and network to address inscriptions used by Immutable Mobiles (IM) and design a method to take advantage of IMs. Then we explain how this method can address situations of technological innovation using the ecography example. We then present our main tools (programs of action and taxonomical trees of names) and we exercise them in the description of the mouse case-study. Our tools are based on the internetworking of names that negotiate their meanings. The two first short stories addressed are situated in a micro level analysis. Then, taking advantage of the concept of global value chain we explore natural to social and from local to global is a simplified way to describe the mediation that is always a messy work in the margins, Le goût des marges (Latour, 1991). To be able to follow the paths of mediation, the referents that enable the understanding of events and actor's work, we reinterpret Latour's formulation as depicted in Figure 2. In our research we approach the description of some cases of innovation with this ANT based view as a method to understand the management of engineering design processes. That is, what we are trying to do is to figure out a practical way to navigate the work of mediation, a way to register the referents that allows the building of innova- tions. Figure 1. Ontological regions and the mediation work, adapted from Latour (1991)