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Chapter 7. Late-onset neurodegenerative ... > Proteinopathies, induction of misfol...

Proteinopathies, induction of misfolding, and formation of protein aggregates

In some cases, changes can be identified in genes that encode the proteins that are precipitated. In many cases, gene changes are not detected, but specific proteins precipitate and form aggregates. Why? Does gene expression change so that larger quantities of the specific protein are formed? Do cellular factors change and promote secondary modification?

In reviewing the formation of amyloid aggregates, Holtzman (2004) noted that normally amyloid Abeta peptide has a random coil and alpha helical structure, and is soluble. Pathological changes involve conversion of that form to a beta sheet formation.


  

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