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Chapter 5. Pathways, phenotypes, and phe... > Regulation of mTOR expression by str... - Pg. 72

72 I NVESTIGATING THE H UMAN G ENOME mTOR and bioenergetic regulation in cancer Many tumors are characterized by active glycolysis and apoptosis resistance. Khatri, et al. (2010), demonstrated that mTORC1- dependent glycolysis increases when levels of the FOX3A transcription factor decrease. Their studies further revealed that FOX3A knockdown leads to decreased expression of the TSC1 gene and increased expression of mTORC1. Regulation of mTOR expression by stress Expression levels of mTOR change in response to signals from growth factors, nutrient levels, cellular energy levels, and stress con- ditions. Specific stressors that impact mTOR expression include