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According to the American Lung Association (2006), lung disease is the fourth leading cause of death in the United States. More than 35 million Americans live with chronic lung disease. Some of these diseases, such as asbestosis, are the result of occupational exposure and carry associated risks of lung cancer. Respiratory infections, particularly nosocomial pneumonia, are responsible for 11% of all hospital-acquired infections. This chapter covers common noninfectious disorders that contribute to chronic lung disease, occupational lung disorders, infectious diseases of the lower respiratory tract, acute respiratory disorders that threaten the client’s life, and emerging pulmonary infections.