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21.2 Synopsis

The null hypothesis tested by the log-rank test is that of equal event time distributions among groups. Equality of the distributions of event times implies similar risk-adjusted event rates among groups not only for the clinical trial as a whole, but also for any arbitrary time point during the trial. Rejection of the null hypothesis indicates that the event rates differ among groups at one or more time points during the study.

Here, you will examine the case of two independent groups, although the same method is easily extended to more than two groups. A typical data-set layout has the following form, where Y represents the time from initial treatment to the event occurrence, and a † indicates a censored value.


  

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