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Every major upgrade to Mac OS X results in software compatibility problems, where some applications work poorly or don't launch at all. Even in the best cases, most of us will have to update a few applications to get them to work correctly under Leopard.
If history is any indication, some incompatible applications won't be updated right away, and a few might never be. But many developers work hard to ensure that their software is ready for each new version of Mac OS X, and "Leopard-compatible" software updates have already been appearing for months.