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If you're still using that crummy one‐button mouse that came with your iMac, G3, or G4, do yourself a favor and beat it to death with a hammer. Then buy a real mouse. You'll be so much happier if you upgrade to a mouse that's easier to move around, more comfortable to use, and maybe even has two or more buttons and/or a scroll wheel. You'll be amazed at how much easier it is to work with a mouse that fits your hand. OS X knows all about multibutton mice and scroll wheels. And with a two‐button mouse, you no longer have to hold down the Control key while clicking to display a contextual menu — you can just right‐click.
Also consider ditching the silly little keyboard that came with your iMac, eMac, Power Mac, Mac Pro, or whatever. Third‐party Mac keyboards on the market today are a huge improvement over what probably came with your Mac.