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Chapter 23, “Developing COM Add-Ins for Word and Excel,” examined several issues with building COM add-ins in C# for Office applications. In particular, the chapter considered several problems with using the default configuration of a COM add-in where mscoree.dll loads the COM add-in:
Mscoree.dll can be disabled, causing all managed COM add-ins to stop loading.
Mscoree.dll cannot be signed, which makes it so your COM add-in cannot be loaded when the Trust all installed add-ins and templates option is not checked.
Mscoree.dll loads all COM add-ins into the same application domain, which allows COM add-ins to affect one another adversely.