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Whether you're a business or an individual on Twitter, if you want to grow your Twitter network, it's helpful to think about your audience. If you haven't transplanted your existing social networks onto Twitter, it may be a good time to do that and to put a bit of time and effort into expanding your network.
Think about the kinds of people you'd like to talk to or the subjects you'd like to discuss through Twitter. Trying to build up business? Target your customers. Want to communicate with other avid cyclists on Twitter? Search keywords and look to see who tweets about major cycling events. Send updates that are relevant to whomever you'd like to reach or about the topics that interest you and engage yourself in that conversation. Yes, it's that easy.